Mississippi River cruises offer travelers a unique and immersive way to experience the heartland of America while exploring historic cities, charming towns, and scenic landscapes along one of the world’s most iconic rivers.

Mississippi River Cruise Highlights

One of the main attractions of a Mississippi River cruise is the opportunity to visit historic river cities like New Orleans, Memphis, St. Louis, and Natchez. These cities are steeped in rich history, culture, and architecture, and passengers can explore them through guided tours, museum visits, landmark excursions, and cultural experiences.

As you cruise, you’ll be treated to scenic views of rolling hills, lush forests, and picturesque river towns. Whether navigating the bluffs of the Upper Mississippi or the bayous of the Lower Mississippi, the breathtaking vistas are a highlight of the journey, best enjoyed from the comfort of the ship’s deck.

A Mississippi River cruise also offers a taste of Southern hospitality. Onboard amenities often include live music, regional cuisine, and cultural performances, allowing you to immerse yourself in the flavors and traditions of the South. Lectures and presentations provide valuable insights into the region’s history, music, and culinary delights, adding depth to your travel experience.

Many cruises also include visits to antebellum plantations and historic estates, offering a glimpse into the region’s plantation-era past. These visits allow you to tour beautifully preserved mansions, gardens, and slave quarters, while learning about the history of the Old South and the legacy of slavery.

For an extra touch of nostalgia, some cruises are conducted aboard authentic paddlewheel riverboats. These vessels evoke the romance of a bygone era with period décor, live entertainment, and outdoor observation decks, offering passengers an intimate view of the river’s charm.

Food lovers will be delighted by the region’s culinary offerings, which are often showcased throughout the cruise. Onboard dining experiences feature Southern cuisine and local specialties, including gumbo, barbecue, fried catfish, and pecan pie, along with regional wines and spirits that enhance the overall experience.

Finally, themed cruises add a special twist to the journey, with itineraries focused on specific interests like music, history, or cuisine. These cruises offer curated events, guest speakers, and excursions tailored to the passions and preferences of passengers, ensuring a customized and enriching experience.

This was the best experience of my husband and my Life. We traveled from Memphis to New Orleans. Weather was awesome, the crew top-notch, food the best ever. Can’t wait to do it again.

— Cindy G.

Mississippi River Cruise Itineraries

Mississippi River cruising

Historic Mississippi River Cruise

Embark on an 8-day Historic Mississippi River Cruise, sailing roundtrip from New Orleans aboard one of American Cruise Lines’ brand-new riverboats. This extraordinary journey celebrates the vibrant culture and rich history of a region where music resonates universally and every bend in the river reveals a new chapter of the past.

Houmas House, Louisiana

Lower Mississippi River Cruise

Embark on an 8-day Lower Mississippi River cruise, sailing between the lively streets of New Orleans, Louisiana, and the soulful rhythms of Memphis, Tennessee. This exciting voyage along the Lower Mississippi River promises discovery at every turn.

The Arch in St. Louis with springtime cherry blossoms

Upper Mississippi River Cruise

Embark on a thrilling 9-day Upper Mississippi River Cruise, where each moment is infused with the charm of Americana and the awe-inspiring beauty that has long captivated the hearts of writers, artists, and musicians alike.

The Grand Ole Opry with a guitar in the foreground

Music Cities Cruise

On this 9-day Music Cities Cruise, embark on an unforgettable journey from Memphis to Nashville, where the mighty Mississippi, the powerful Ohio River, and the peaceful Cumberland River lead you through awe-inspiring landscapes.

Churchhill Downs

Ohio River Cruise

Embark on a 9-day Ohio River Cruise from Louisville, KY to Pittsburgh, PA, where you’ll immerse yourself in the heart of America’s history and natural beauty along the iconic Ohio River.

Pittsburg, with multiple river meeting and a gondola in the foreground

Grand Ohio River Cruise

Embark on a 16-day Grand Ohio River Cruise, where you’ll journey through two of America’s most storied rivers, the Ohio and the Mississippi, immersing yourself in the heart of the nation’s landscape.

Cannon at military cemetery in Tennessee

Tennessee Rivers Cruise

Embark on a 9-day Tennessee Rivers Cruise aboard an American Cruise Lines modern riverboat, and experience the rich history and musical heritage of the Tennessee Valley.

American Cruise Lines ship docked along the Mississippi River, with a historic fort in the foreground

Grand Heartland Cruise

Embark on a 16-day Grand Heartland Cruise, where you’ll traverse the iconic Mississippi River, delving into the heart of American history and witnessing the evolving landscapes that have shaped the nation.

Viking Mississippi in New Orleans

New Orleans & Southern Charms

Embark on an 8-day adventure through New Orleans & Southern Charms along the mighty Mississippi River. Explore historic estates and significant Civil War landmarks while discovering the vibrant port cities of New Orleans and Baton Rouge, with their French-inspired charm.

Plantation House

Mississippi Delta Explorer

Embark on an 8-day journey aboard the 386-guest Viking Mississippi on the Mississippi Delta Explorer cruise. Discover Darrow, the gateway to the grand estates of the Lower Mississippi, and explore charming towns along the river that preserve the early history of the American South.

American Cruise Lines ship sailing the Mississippi River

Complete Mississippi River Experience

Embark on the epic 23-day Complete Mississippi River Experience, starting in New Orleans and traveling north, with a new port of call each day, culminating in Minneapolis. Along the way, American Cruise Lines’ onboard experts bring the stories of the River to life, offering rich context to every shore excursion.