At a glance
- Duration:
- 23 Days
- Start/End:
- New Orleans, LA to St. Paul, MN
- From:
- $15,890
- Time of Year:
- May - June
Embark on the epic 23-day Complete Mississippi River Experience, starting in New Orleans and traveling north, with a new port of call each day, culminating in Minneapolis. Along the way, American Cruise Lines’ onboard experts bring the stories of the River to life, offering rich context to every shore excursion.
The Mississippi River is woven into the fabric of American history and culture. Its banks have inspired countless literary works, including those by Mark Twain, and have been a muse for legendary artists and musicians such as Louis Armstrong and Elvis Presley. This comprehensive journey lets you experience it all in the most extraordinary way.
This ultimate Mississippi cruise takes you along the entire length of the river, stopping at iconic ports like New Orleans, Memphis, Hannibal, Winona, and more.
From northern Minnesota to the Gulf of Mexico, the Mississippi River offers a truly American cruising experience. With over 50 years of expertise and a fleet of modern luxury riverboats, American Cruise Lines is the top operator of Mississippi River cruises. This itinerary offers more opportunities to explore the river than any other cruise line, while our state-of-the-art riverboats provide spacious staterooms, private balconies, and complimentary excursions at every port.
Complete Mississippi River Experience Details
Day-to-Day Itinerary
Day 1: New Orleans, LA
Welcome to New Orleans, a city renowned for its vibrant nightlife and lively music scene, where jazz, blues, and zydeco tunes fill the air at every turn. A fusion of French, African, and American influences come together to create the iconic dishes this city is famous for. As you settle into your hotel, take some time to explore at your own pace. Stroll through the historic French Quarter, let the delicious aromas of gumbo and beignets lead you, and admire the lush greenery hanging from windowsills, intricate iron balconies, and the pastel-colored Creole townhouses that line the charming cobblestone streets.
Day 2: Day of River Cruising
Board your ship and say farewell to New Orleans as you kick off your journey with a Welcome Reception—an ideal chance to meet fellow travelers and begin your unforgettable Mississippi River adventure. As the ship sets sail, prepare to witness the breathtaking vistas that have inspired some of America’s most iconic writers, artists, and musicians.
Day 3: Oak Alley, LA
Once a prosperous sugar cane plantation, Oak Alley is named for its most captivating feature: a breathtaking canopy of towering oaks, their timeworn branches gracefully arching to create a verdant aisle that stretches along the river. At the heart of this majestic site stands the mansion, an embodiment of Greek Revival elegance, its soaring columns reaching for the sky, a timeless symbol carved in white marble. Restored to its nineteenth-century splendor, this grand structure stands as a solemn yet striking guardian of history, captivating in its quiet, enduring beauty.
Day 4: Houmas House, LA
Houmas House Estate is a symbol of Southern elegance, nestled in the heart of Louisiana’s countryside, with deep historical ties to sugar cane cultivation. Surrounded by towering ancient oaks and carefully manicured gardens, the mansion boasts timeless architecture, complete with sweeping staircases and luxurious rooms that offer a glimpse into the life of the Southern elite. Known as “The Sugar Palace,” this estate is a stunning display of vibrant blooms and lush greenery, providing an inviting setting for visitors to discover its charm and beauty.
Day 5: Baton Rouge, LA
Originally named after a “red stick” marker used by Native Americans, Baton Rouge is now the historic capital of Louisiana. The city resonates with the legacies of its most prominent figures, particularly the influential Governor and Senator Huey P. Long. His political and architectural contributions are preserved at the Old State Capitol Museum, set in a stunning Gothic-style castle built in 1852, and the towering 34-story State Capitol, a striking example of Depression-era art deco design crafted from Louisiana limestone and adorned with marble.
Stroll through the heart of Baton Rouge’s downtown, where modern art installations contrast with classical revival and sleek modernist buildings. For a deeper connection with the natural world, hop aboard a boat for a guided tour through the nearby swamps, teeming with alligators and cypress trees draped in Spanish moss.
Day 6: St. Francisville, LA
St. Francisville, Louisiana, offers a captivating blend of small-town charm and Southern Gothic allure. Known for its well-preserved historic homes, the town is home to the Myrtles, widely regarded as one of America’s most haunted houses, as well as the elegant Rosedown, surrounded by 28 acres of stunning gardens.
Wander through the picturesque Historic District, where grand mansions and unique boutiques invite exploration. Experience the striking contrast of towering cottonwood trees giving way to majestic oaks draped in Spanish moss, creating an atmosphere of timeless beauty.
Day 7: Natchez, MS
In the heart of Natchez, where the mighty river winds and curves, grand homes rise, reflecting the opulence of a bygone era. Founded in 1716 by the French, amidst the Natchez Indian community, this town quickly flourished into a prosperous river hub.
Step into the legacy of 1800s planters who transformed their visions into majestic mansions. Unscathed by the ravages of the Civil War, Natchez remains a rare and untouched gem. Stroll through its winding streets, where time seems to stand still, and discover the legendary Under-The-Hill Saloon, a cherished relic of a bygone era, still echoing the stories of days long past.
Day 8: Vicksburg, MS
In the heart of Mississippi stands Vicksburg, a pivotal battleground of the Civil War. Known as “The Gibraltar of the West,” its strategic significance was undeniable to President Lincoln. The National Military Park honors the stories of courage and sacrifice that shaped the nation. Along the floodwall, murals vividly depict Vicksburg’s history, each one a powerful stroke on the canvas of memory. Amidst the towering legacy of Vicksburg, the weight of the past is felt deeply, a testament to the enduring spirit of a nation forged through the trials of war.
Day 9: Greenville, MS
Known as the Heart and Soul of the Mississippi Delta, Greenville offers a captivating look at traditional Southern living. Discover historic landmarks like Cotton Row, Mount Holly Plantation, and the Weatherbee House, each steeped in the rich history of the region. As you explore the city’s vibrant past, feel the timeless charm of Greenville surround you. When the sun sets over Lake Ferguson, you’ll be drawn into the city’s enduring allure, becoming a part of its ever-evolving story.
Day 10: Tunica, MS
Nestled in the heart of the Delta, Tunica stands as a living testament to history and charm. Its Main Street, unchanged since the turn of the century, is lined with buildings that have withstood the test of time, each telling the story of a bygone era. Wander through distinctive boutiques and antique shops, where the past is beautifully preserved. Admire the fully restored courthouse, a symbol of justice, and visit the Tunica Veterans Memorial at Rivergate Park, honoring the bravery of generations. Tunica invites you to experience its warm Southern hospitality, a timeless port town waiting to be explored.
Day 11: Memphis, TN
Welcome to Memphis, where history comes alive with every beat. Stroll down Beale Street, where the sounds of legendary musicians still echo through the air. Savor the city’s famous BBQ, dripping with sweetness, and explore historic sites that honor the Civil War and Civil Rights Movement. Don’t miss a taste of crispy fried catfish, a Southern classic that captures the essence of Memphis.
Step into the birthplace of rock ‘n’ roll at Sun Studio, where Elvis Presley recorded his first hits, and immerse yourself in the rhythm and blues that pulse through the city’s veins. Finally, relax aboard your ship at Beale Street Landing, serenaded by local musicians beneath the stars as you reflect on your day’s adventures. Welcome to Memphis – a city where every moment is a song waiting to be heard.
Day 12: Cape Girardeau, MO
Cape Girardeau is a hidden gem along the river, full of history, charm, and that unmistakable Midwestern spirit. This port city has a story to tell, and you can uncover it through vibrant murals that capture the highs and lows of its past. Stroll along its quaint streets, explore unique shops, and walk the train tracks that highlight the city’s role in trade. Here, you’ll feel even closer to the mighty Mississippi.
The Old Bridge Overlook offers breathtaking views as the river winds lazily below, a perfect spot to pause and take it all in. Step back in time at the Cape River Heritage Museum, where history is brought to life through engaging exhibits and captivating stories.
Day 13: Day of River Cruising
Today is not just about reaching our destination; it’s about savoring the journey, especially as we glide along this iconic waterway. Take a moment to head up to the sun deck and soak in the breathtaking landscapes and picturesque towns nestled along the riverbanks. Keep an eye out for the impressive wildlife that calls this majestic river home.
As we sail, our onboard expert will share captivating stories about the native creatures that thrive in these waters. Today is a time to slow down, appreciate the beauty around you, and let the peaceful rhythm of the river calm your spirit.
Day 14: St. Louis, MO
As we near this iconic destination, watch as the skyline of St. Louis emerges on the horizon, a striking symbol of the city’s rich history and vibrant energy.
As we draw closer, take in the views of this dynamic Midwestern city, from the soaring Gateway Arch to the charming neighborhoods that pulse with life. Don’t forget to indulge in some local treats, like gooey butter cake and toasted ravioli.
As we cruise along the river, our onboard expert will share fascinating stories about St. Louis’s pivotal role in shaping the nation and its thriving cultural scene. Or, simply find a spot on deck to bask in the sun and admire the beauty of the Mississippi as it flows peacefully by.
Day 15: Day of River Cruising
As we cruise toward the historic city of Hannibal, take in the beauty of the heartland as it unfolds around you. Whether you choose to socialize with fellow guests in one of our lounges, get lost in a great book on your private balcony, or participate in one of our engaging onboard activities, there’s something for everyone to enjoy. Be sure to join us for cocktail hour to swap stories with new friends before sitting down to a river-inspired dinner, thoughtfully curated for your enjoyment.
Day 16: Hannibal, MO
Nestled along the river’s edge, this delightful town offers a true taste of Americana. Cobblestone streets echo with the memories of Mark Twain’s boyhood adventures, making it a place of literary significance. Charming Victorian homes line the riverbanks, their vibrant colors reflecting the town’s rich character. The spirit of Twain’s beloved characters, Tom Sawyer and Huckleberry Finn, seems to linger in the air, inviting adventure at every turn. From the iconic white picket fence of the Mark Twain Boyhood Home to the charming Becky Thatcher House, every corner of Hannibal tells a story waiting to be explored.
Day 17: Day of River Cruising
Relax into one of our spacious lounges aboard the riverboat, where you can dive into a captivating book as we journey from Hannibal to Muscatine. Alternatively, unwind on the sun deck or your private balcony, soaking in the ever-changing scenery as we glide along. Let the gentle sway of the river guide you into a peaceful rhythm, with each bend revealing a fresh, breathtaking view. Whether you seek quiet reflection or friendly conversation, there’s no better place to embrace the beauty of the heartland than aboard our riverboat.
Day 18: Muscatine, IA
Nestled along the winding banks, Muscatine is a perfect blend of natural serenity and enduring resilience. The river’s gentle flow carries the echoes of both past and present, offering a peaceful backdrop to this historic town. At the heart of the city, the Pearl Button Museum celebrates Muscatine’s unique legacy, while the Pine Creek Grist Mill stands as a proud reminder of the community’s perseverance. Stroll down charming streets lined with historic buildings, each one a testament to a bygone era. As the sun sets, casting golden and orange hues across the sky, Muscatine’s timeless beauty enchants all who are fortunate enough to experience it.
Day 19: Dubuque, IA
Dubuque, one of the oldest settlements west of the Mighty Mississippi, boasts a history as deep and rich as the river that flows beside it. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway, for breathtaking views of the city and the river below.
Wander through the vibrant landscape, where colorful Victorian mansions stand as proud reminders of Dubuque’s storied past and architectural heritage. No visit would be complete without exploring the National Mississippi River Museum & Aquarium, where the fascinating river ecosystem comes alive through interactive exhibits and immersive displays.
Day 20: Day of River Cruising
As you cruise from Dubuque to Winona, take in the stunning beauty of the Midwestern shoreline from the comfort of your private balcony. Let the peaceful river and picturesque towns along the way inspire you as you drift through serene landscapes. Feel the calming rhythm of the water, guiding you along this historic route. This journey isn’t just about the destination—it’s a chance to pause, appreciate the moment, and soak in the surroundings.
Day 21: Winona, MN
Nestled among the rolling bluffs, Winona, Minnesota, radiates a quiet elegance. Its charming streets, adorned with Victorian-era architecture, offer a glimpse into the past, while the river’s gentle flow carries stories from centuries ago. The city’s artistic spirit flourishes in its vibrant cultural scene, with the Minnesota Marine Art Museum showcasing stunning works inspired by the river’s breathtaking beauty. Take a stroll through fields of prairie flowers or simply relax as the sun sets, casting a golden hue over the bluffs and river below. Winona’s timeless allure lingers long after you’ve left its scenic shores.
Day 22: Red Wing, MN
Perched on the northern riverbanks, Red Wing has inspired craftsmen and artists for over 150 years. With its stunning cliffs and expansive river vistas, the city has been a muse for creativity and art. Immerse yourself in the vibrant cultural scene at the historic Sheldon Performing Arts Theatre, where world-class performances await. Or, explore the natural beauty of Red Wing’s 38 parks, each with its own unique charm—from the peaceful riverside trails of Colvill Park to the lush greenery of Barn Bluff. Whether you seek artistic inspiration or outdoor adventure, Red Wing beckons with the magic that has captivated generations.
Day 23: St. Paul, MN
As your riverboat adventure on the Mighty Mississippi comes to a close in St. Paul, prepare for a final chapter full of discovery. History enthusiasts will appreciate a walk down Summit Avenue, where you’ll encounter magnificent 19th-century mansions. Explore charming art galleries, world-class museums, and captivating performances that will spark your imagination. As the day draws to a close, visit Mounds Park for a breathtaking panoramic view of the city—a perfect conclusion to your unforgettable journey.
And just like that, we’ve arrived at the end of this remarkable Mississippi odyssey. From the sounds of Memphis to the literary legacy of Hannibal, you’ve experienced it all. As you return home, American Cruise Lines extends its heartfelt thanks for joining us. We hope to welcome you aboard again soon.
