Pittsburg, with multiple river meeting and a gondola in the foreground

Grand Ohio River Cruise

At a glance

Duration:
16 Days
Start/End:
Pittsburgh, PA to St. Louis, MO
From:
$8,075
Time of Year:
June - August
Request Your Brochure Book this Trip
or call us toll-free 1-888-815-5428
American Cruise Lines

On this 16-day Grand Ohio River Cruise, experience two of America’s greatest rivers through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain.

Each port of call brings a fresh encounter with the spirit of Americana, from the quaint riverbanks of Ohio and Kentucky to the industrious spirit of Pittsburgh and the historic charm of St. Louis. Aboard one of our Modern Riverboats, experience the pivotal eras of the Civil War and the Civil Rights Movement as you navigate these iconic waterways.

In Henderson, KY, explore the Audubon Museum, a sanctuary of original artworks that illuminate the profound influence of John James Audubon on America’s appreciation for the natural world. Venture further into the creative realms at the National Quilt Museum in Paducah, renowned globally for its extensive and beautifully curated collection of quilt and fiber arts. In Louisville, experience the thrill of Churchill Downs, the heart of the Kentucky Derby, with an exclusive behind-the-scenes look at this hallowed ground of horseracing.

As the day wanes, retreat to the comfort and elegance of your ship. Dine in our refined restaurant, where culinary delights meet engaging conversation, and each meal is inspired by the ports you visit.

Navigating the Ohio River is an exercise in flexibility and wonder, shaped by the whims of its waters. Our itineraries are crafted with care, yet open to the spontaneous rhythms of river currents. Come aboard for an exquisite encounter with America’s iconic rivers, where history and nature dance along the water’s edge.

Grand Ohio River Cruise Details

Day-to-Day Itinerary

Pittsburg, with multiple river meeting and a gondola in the foreground

Day 1: Pittsburgh, PA

Pittsburgh, once the beating heart of manufacturing, played a pivotal role in shaping the corridors of national and international commerce along the Ohio River. This industrious city flourished in the 18th and 19th centuries, its wealth evident in the grand architecture and the spirit of innovation that still permeates its streets. Upon your arrival, settle into your hotel, then step out to wander the city at your own pace.

Discover the legacies of American titans like Heinz and Carnegie, who planted their roots in this dynamic city. As you meander through the city, you’ll feel the echoes of a rich past intermingling with the vibrant, forward-looking energy that defines Pittsburgh today.


Pittsburgh, PA

Day 2: Pittsburgh, PA

Our vessel moors at the historic junction where the Allegheny and Monongahela Rivers converge to form the majestic Ohio River. Upon boarding, make your way to your stateroom to unpack and get comfortable on your private balcony. As we set sail and cruise from Pittsburgh, enjoy the ever-changing landscapes that unfold from the deck—scenes reminiscent of those witnessed by the earliest navigators of these waters.


The Ohio River

Day 3: Day of Cruising

Cruise along this scenic riverside route on a journey filled with sweeping views of the Ohio River and charming small towns along the way. As you wind through lush forests, gently rolling hills, and quiet valleys, delight in a peaceful escape from the bustle of city life. Pass through vibrant riverfront communities and admire glimpses of historic buildings and local marinas, each telling its own unique story. Approaching Marietta, the city’s rich heritage as one of the oldest settlements in the Northwest Territory comes into view, with its well-preserved architecture and welcoming small-town atmosphere.


The Castle Historic House Museum in Marietta, a victorian-style brick mansion with small, ornate turrets and large windows surrounded by greenery and purple flowers.

Day 4: Marietta, OH

This quaint town sits at the meeting place of the Muskingum River and the Ohio River, home to five National Register Historic Districts featuring buildings that have stood since its founding in 1788. Stroll through the earliest settlement in the Northwest Territory, on the north side of the Ohio River. Listen to the stirring stories of significant events that unfolded here, as detailed in The Pioneers, the recent book by Pulitzer Prize-winning historian David McCullough.


A couple sits at a table beside an American flag on an American Cruise Lines Coastal Cat's sun deck looking out at the Florida Coast, while a man sits to the right of them typing on his computer.

Day 5: Day of Cruising

Today is all about carefree enjoyment. Make the day your own and engage in fascinating presentations and fun-filled onboard activities. Enjoy gourmet meals and signature cocktails, and don’t miss freshly baked cookies at 3pm. Relax in our expansive lounges or feel the soft breeze on the sun deck, a prime spot for getting lost in a good book or engaging in conversations with new friends. It’s your day to simply relax and have a great time.


American Heritage paddlewheeler docked letting passengers off from the front of the white ship. It is decorated with patriotic red white and blue bunting flags on every railing.

Day 6: Maysville, KY

From your vantage point on the ship’s deck, take a moment to appreciate the scenic charm of Maysville, tucked into the hillside. This town marks a historic location, where early flatboat merchants, after trading down the Mississippi to New Orleans, journeyed back via the Natchez Trace Pathway to reconnect with the Ohio River.

Explore the town’s pivotal role in the Underground Railroad, where daring escapes across the river were orchestrated. Uncover the story of Harriet Beecher Stowe’s visit, which profoundly influenced her writing of the classic story Uncle Tom’s Cabin. You’ll also enjoy tales of notable locals such as the bold explorer Simon Kenton and the beloved singer and actress Rosemary Clooney.


A large Pinocchio sculpture with his arms outstretched looking up to the sky stands in front of the Cincinnati Art Museum, a light brick building with four pillars and several stairs leading up to the door.

Day 7: Cincinnati, OH

The striking bridges spanning the Ohio River create a magnificent entrance to Cincinnati, affectionately known as the “Queen City.” Originally a key shipbuilding and shipping metropolis, it has transformed into a dynamic cultural hub. Here, you can explore top-notch sports teams, the delightful Cincinnati Zoo and Botanical Garden, numerous theaters, and a range of museums, including the renowned National Underground Railroad Freedom Center, a Smithsonian Affiliate Museum.

Take a leisurely walk through the city streets, taking in the diverse architectural styles. Notable spots include the expansive Krohn Conservatory and the majestic St. Mary’s Cathedral Basilica. For a dish just as unique as the city itself try Cincinnati Skyline Chili or enjoy a scoop of ice cream from Graeter’s, a cherished establishment since 1868.


A fountain in the heart of Madison, IN.

Day 8: Madison, IN

A quaint town located on the banks of the Ohio River, Madison is one of the oldest and most charming cities in the state, known for its well-preserved 19th-century architecture. The historic district, listed on the National Register of Historic Places, features over 130 preserved buildings that showcase a mix of Greek Revival, Victorian, and Federal styles.

With several local sites linked to the abolitionist movement, Madison’s rich history includes a significant role in the Underground Railroad. The town also celebrates its heritage during the Madison Regatta, one of the oldest hydroplane races in the U.S.

Considered an outdoor museum of architecture, stroll through the vibrant downtown which abounds with boutique shops, art galleries, and restaurants. Take time to admire the town’s natural beauty, with scenic views of the river and surrounding hills serving as a picturesque backdrop.


A giant wooden Louisville Slugger baseball bat leans against a red brick building, Hillerich & Bradsby Co., with "Louisville Slugger" in gold writing on the left side of the building surrounded by bright green vines in Louisville.

Day 9: Louisville, KY

Louisville, a vibrant waterfront town, climbs gracefully up the hillside, its spirit etched deep into the fabric of American history. This city first flourished as a crucial portage around the perilous Falls of the Ohio, now tamed behind the expansive sweep of the Ohio River’s Markland Dam.

Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby—the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted.

No visit to Louisville would be complete without experiencing its famed bourbon heritage. Tour a local distillery, where the rich aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and the history of Bluegrass country.


Two couples onboard an American Cruise Lines shop toasting at a dining table, with the Mississippi River through the windows in the background

Day 10: Day of Cruising

As you cruise along the grand Ohio River, experience the serene beauty of America’s heartland. Witness the gentle sweep of greenery along the banks, interspersed with quaint towns that can be seen from the top deck. Partake in a variety of onboard activities designed to enrich your journey, from historical presentations to lively discussions, each adding depth to the stunning vistas that unfold before you. Let the rhythm of the river carry you through landscapes steeped in history, offering a peaceful yet engaging backdrop to your exploration. Each mile traveled is a new chapter in the unfolding story of the Ohio River, inviting you to witness its quiet waves and enduring charm.


A view of Henderson, Kentucky from onboard an American Cruise Lines

Day 11: Henderson, KY / Evansville, IN

Henderson, a relaxed river town, is imbued with stories and a deep sense of community. This town also served as the creative sanctuary for naturalist and artist John James Audubon in the early 1800s, where he crafted many of his stunning “Birds of America” masterpieces.

Just down the river, discover Evansville, a city that harmoniously blends contemporary and historical architecture. As the site of Bally’s Evansville, Indiana’s inaugural casino, the city offers a unique vibrancy alongside tranquil cultural sites like Mesker Park Zoo and Botanic Garden, one of the state’s oldest and largest zoos. Experience the local culture with visits to the city’s diverse museums and enjoy leisurely shopping and strolls through the enchanting streets of this scenic waterfront town. Each corner of Evansville offers a delightful mix of past and present, inviting visitors to explore and enjoy its unique charm.


American Cruise Lines ship sailing the Mississippi River

Day 12: Day of Cruising

Today, be on the lookout for the diverse array of wildlife that thrives in this region’s rich ecosystem. Spot majestic white-tailed deer gracefully bounding through the meadows, while cunning red foxes dart among the trees. Don’t forget to watch for the adorable cotton-tail rabbits that scamper across the riverbanks, adding a touch of charm to your scenic journey. With every passing moment, the Ohio River reveals its vibrant and captivating tapestry of life, ensuring an unforgettable cruise experience filled with energy and excitement.


Paducah, KY

Day 13: Paducah, KY

Just upstream from your ship’s mooring, the Tennessee River flows into the mighty Ohio River, painting a stunning portrait. Nearby, the confluence with the Cumberland River and the iconic Mississippi adds to the riverine symphony, creating a dynamic crossroads at the heart of Paducah’s maritime legacy.

As you stroll along the bustling riverfront landing, you’ll encounter a visual feast: over 50 intricate murals that vividly depict Paducah’s dynamic history. These murals chronicle the town’s pivotal moments, from its strategic significance during the Civil War to its emergence as a bustling river port that shaped the destiny of a nation.

For an artistic delight, visit the National Quilt Museum, located a mere block from the riverfront. Here, you’ll be awestruck by an extraordinary collection of quilts, each an amazement in its own right and a testament to the skill of its artisans.


Passengers on deck viewing the passing scenery

Day 14: Day of Cruising

On a journey from the Ohio River to the Mississippi River, make your way to St. Louis, MO. Engage in onboard activities like trivia sessions in the lounge or relax on the top deck. You can always unwind on your private balcony and savor the idyllic countryside and panoramic river vistas as they roll by.


The view of the St. Louis Arch and skyline from the deck of an American Cruise Lines ship.

Day 15: St. Louis, MO

Prepare to be captivated by the irresistible charm of St. Louis. Take in the sweeping riverfront vista, dominated by the iconic Gateway Arch, a towering testament to human ingenuity and ambition, proudly standing as the largest man-made monument in the U.S.

Engage yourself in the city’s wealth of world-class attractions, each offering a unique glimpse into St. Louis’ rich history and culture. Explore the fascinating stories of the mighty Mississippi River at the National Great Rivers Museum, where tales of the river’s past, its people, and its diverse ecosystems are recounted.

Discover the annals of time at the Missouri History Museum, situated within the expansive expanse of Forest Park, a site with a legacy tied to the legendary 1904 World’s Fair. Stand in awe beneath the resplendent mosaic tile interior of the Cathedral Basilica, a testament to the city’s enduring faith and architectural prowess.

Celebrate the spirit of American resilience and innovation at the newly renovated Gateway Arch monument, a beacon of the nation’s western expansion, and its groundbreaking underground museum, offering a journey through history like no other. In St. Louis, every corner reveals an array of experiences, beckoning you to explore, uncover, and be inspired.


The Arch in St. Louis with springtime cherry blossoms

Day 16: St. Louis, MO

Conclude your grand Ohio River voyage in this distinctive city, boasting frontier-town roots and the unassuming charm of the Midwest. As you journey homeward, take a moment to reminisce about the myriad of remarkable experiences you’ve encountered, or seize the opportunity to stay a little longer in the Gateway to the West.


Grand Ohio River Cruise Itinerary Map

Dates & Rates

Scroll for more rates →
Dates & Rates - Mississippi River - ACL - Grand Ohio River Cruise
DateShipStandard WaterviewStandard BalconyDeluxe Balcony 2Deluxe BalconyDeluxe Balcony 1Premium BalconyVeranda SuiteGrand SuiteSingle WaterviewSingle Balcony
Friday, June 20, 2025American MelodySold OutSold OutSold OutSold OutSold OutSold Out
Friday, August 15, 2025American MelodySold Out$9,675Sold OutSold OutSold OutSold Out
Monday, August 25, 2025American HeritageSold OutSold Out$9,120$9,675Sold OutSold OutSold OutSold Out
Friday, June 19, 2026American Melody$9,240$10,175$10,785$12,675$16,230Sold Out
Friday, June 19, 2026American Melody$9,240$10,175$10,785$12,675$16,230Sold Out
Saturday, August 1, 2026American Melody$9,240$10,175$10,785$12,675$16,230$11,745
Saturday, August 1, 2026American Melody$9,240$10,175$10,785$12,675Sold Out$11,745
Saturday, August 22, 2026American Heritage$8,075$9,240$9,620$10,175$10,785$12,675$10,625$11,745
Friday, June 18, 2027American Melody$9,240$10,175$10,785$12,675$16,230$11,745
Friday, August 13, 2027American Melody$9,240$10,175$10,785$12,675$16,230$11,745
Friday, August 27, 2027American Heritage$8,075$9,240$9,620$10,175$10,785$12,675$10,625$11,745

Dates and rates are effective the date the information was updated on this site. Dates and rates may have changed by the cruise line prior to an update here. Contact Sunstone Tours & Cruises for the latest dates & rates.

Prices subject to change.

Included

  • Cruise passage
  • All gourmet meals
  • Breakfast room service
  • Snacks
  • Cocktail hour each evening
  • Entertainment aboard the ship
  • Acclaimed enrichment program
  • Wi-Fi throughout the ship
  • Personalized service from a dedicated crew

Not Included

  • Air transport to/from embarkation/debarkation destinations
  • Most shore tours (unless otherwise noted)
  • Port charges and fees

Ships

ACL-American Heritage

American Heritage

The 150-passenger American Heritage offers an authentic paddlewheeler experience with all the comforts of home. Guests can enjoy large staterooms with private balconies, hotel-style bathrooms, and complimentary room service.

American Heritage Details …


American Melody

American Melody

The 195-passenger American Melody showcases all the beautiful modern styling and state-of-the-art technical features. The ship features the distinctive opening bow and retractable gangway.

American Melody Details …


Video